This message is about older Windows programs. “Side-by-side” is Microsoft’s system for keeping several versions of the Visual C++ runtime installed at once. The program asked for a specific version — most often the 2005 or 2008 set — and that version isn’t on this PC, or its registration is damaged.
sfc /scannow, then DISM /Online /Cleanup-Image /RestoreHealth.To find the exact missing piece: open Event Viewer → Windows Logs → Application and look for a “SideBySide” error at the time you launched the program — it names the runtime version requested. Or run `sxstrace trace -logfile:sxs.etl` from an admin prompt, launch the program, stop the trace, and convert it with `sxstrace parse`. Either way, install the version it names.
Which redistributable do I actually need? For this message, most often the 2005 SP1 set, then 2008 SP1. Installing 2005, 2008 and 2010 in both flavours covers the overwhelming majority of programs — it takes a few minutes and they don’t conflict.
Did I break something to cause this? No. The runtime was likely never installed on this PC, or a Windows reinstall/upgrade left it behind. The program itself is usually fine.